Peptides and the Central Regulation of Blood Pressure

It is now recognised that a vast number of peptides are present in the central nervous system and that like classical transmitters some of these peptides may participate in the central regulation of the cardiovascular system. These neuropeptides may be colocalised In neurones with other transmitters, such as catecholamines, in brain areas which include the important cardiovascular regulatory region, the medulla oblongata. The peptides reputedly act either independently or they undertake a neuromodulatory role where they may interact with the function of the costored transmitters. Delineation of the cardiovascular actions and possible interactions of peptides found in regions of cardiovascular significance may assist in the understanding of the labyrinthe mechanisms involved in centrally-mediated haemodynamics

High-voltage MOSFET bipolar square-wave generator

he construction of a high‐voltage (up to 1000 V) bipolar metal‐oxide‐semiconductor field‐effect transistor square‐wave generator is described. This generator is capable of producing both positive and negative going square waves with variable amplitude, repetition rate, and width. The circuit was designed for ferroelectrics research, however other applications are possible. The rise time of the prototype was 200 ns which was quite satisfactory for the present ferroelectric research project however the rise time can be decreased to 50 ns if necessary. The reader with a modest knowledge of electronics should be able to construct the circuit. Possible pitfalls and critical points are discussed

New trapdoor-knapsack public-key cryptosystem

The paper presents a new trapdoor-knapsack public-key cryptosystem. The encryption equation is based on the general modular knapsack equation, but, unlike the Merkle-Hellman scheme, the knapsack components do not have to have a superincreasing structure. The trapdoor is based on transformations between the modular and radix form of the knapsack components, via the Chinese remainder theorem. The security is based on factoring a number composed of 256 bit prime factors. The resulting cryptosystem has high density, approximately 30% message expansion and a public key of 14 Kbits. This compares very favourably with the Merkle-Hellman scheme which has over 100% expansion and a public key of 80 Kbits. The major advantage of the scheme when compared with the RSA scheme is one of speed. Typically, knapsack schemes such as the one proposed here are capable of throughput speeds which are orders of magnitude faster than the RSA scheme

Reducing drug related deaths : a pre-implementation assessment of knowledge,barriers and enablers for naloxone distribution through general practice

Peer reviewedPublisher PD

Living with the user: Design drama for dementia care through responsive scripted experiences in the home

Participation in forms of drama and narrative can provoke empathy and creativity in user-centred design processes. In this paper, we expand upon existing methods to explore the potential for responsive scripted experiences that are delivered through the combination of sensors and output devices placed in a home. The approach is being developed in the context of Dementia care, where the capacity for rich user participation in design activities is limited. In this case, a system can act as a proxy for a person with Dementia, allowing designers to gain experiences and insight as to what it is like to provide care for, and live with, this person. We describe the rationale behind the approach, a prototype system architecture, and our current work to explore the creation of scripted experiences for design, played out though UbiComp technologies.This research is funded by the Arts and Humanities Research Council UK, (AH/K00266X/1) and Horizon Digital Economy Research (RCUK grant EP/G065802/1)

'We are still obsessed by this idea of abstinence': A critical analysis of UK news media representations of proposals to introduce drug consumption rooms in Glasgow, UK.

BACKGROUND: Drug consumptions rooms (DCRs) are a well-established and evidence-based harm reduction response to drug use. Recently, a consortium led by health services in Glasgow, United Kingdom (UK), proposed piloting a DCR. In this article, we examine how the proposals were represented in news media reporting, and the possible effects of such reporting. METHODS: A quantitative content and qualitative thematic analysis of UK news media (n = 174 articles) representations of the proposals to introduce DCRs in the city of Glasgow, UK, was conducted. Analysis was informed by Bacchi's (2009, 2012, 2017) approach to policy analysis, 'What's the problem represented to be?' FINDINGS: Competing representations of the 'problem' of injecting drug use (IDU) were contested by a range of actors with different political visions. The applicability of the 'evidence base', potential benefits of DCRs to both users and the public, and the associated economic costs, were presented in differing ways depending on the underlying assumptions and presumptions of the arguments constructed (e.g. harm reduction vs recovery). As a result, a number of conflicting subject positions were presented that may have implications for the way that people who inject drugs (PWID) see themselves, and how they are viewed and treated by society. Whilst proponents positioned DCRs within a discourse of public health, an underlying rhetoric of abstinence and recovery underpinned the arguments against DCRs. It was this latter discourse that underpinned the UK Government's rejection of the proposals, which the Scottish Government were prevented from overruling within the political constraints of their devolved powers, with the lived effect of people who use drugs (PWUD) being denied access to public health services that mitigate harm. CONCLUSION: We conclude that attempts to introduce and gain public and political support for harm reduction responses such as DCRs through the news media face challenges within the historical and political context of prohibitionist UK drugs policy

Assessing the quantity of pulmonary edema in critically ill children

Measuring extravascular lung water may be useful for predicting outcome in adults with acute lung injury. The present commentary briefly reviews the potential role and limitations of extravascular lung water measurement in critically ill children